Patients with solid tumours can be tested with FoundationOne CDx with an FFPE tissue sample. When submitting specimens to Foundation Medicine, please include the following items in the FoundationOne CDx Specimen Kit:

• Appropriate specimen per FoundationOne CDx Specimen Collection Instructions labeled with two patient-specific identifiers
• Completed Test Requisition Form
• Copy of recent pathology/cytology reports

Patients with hematologic malignancies and sarcomas can be tested with FoundationOne Heme, which is performed on FFPE, peripheral whole blood or bone marrow aspirate specimens. When submitting specimens to Foundation Medicine, please include the following items in the FoundationOne Heme Specimen Kit:

• Appropriate specimen per FoundationOne Heme Specimen Collection Instructions, labeled with two patient-specific identifiers
• Completed Test Requisition Form
• Copy of recent pathology/cytology reports

Note for Bone Samples: Do not use strong acids to decalcify. Hydrochloric acid should be avoided; EDTA is recommended, and formic acid has mixed results. Place sample in decalcifying solution for minimal amount of time. Using a weaker acid and shorter time for decalcifying preserves the nucleic acid and increases likelihood for getting results on bone samples.

Patients with solid tumors can be tested using our liquid biopsy, FoundationOne Liquid CDx, which requires two tubes of peripheral whole blood. When submitting specimens to Foundation Medicine, please include the following items in the FoundationOne Liquid Specimen Kit:

• Appropriate specimen per FoundationOne Liquid CDx Specimen Collection Instructions (use only blood tubes provided in the kit
• Completed Test Requisition Form
• Available reports