Genomic Testing

FOUNDATIONONE®Heme

Genomic profiling for hematologic malignancies and sarcomas including but not limited to: Leukemias, Myelodysplastic Syndromes, Myeloproliferative Neoplasms, Lymphomas, Multiple Myeloma, Ewing Sarcoma, Leiomyosarcoma, and pediatric tumours.

USES

Hematologic Malignancies, Sarcomas
SAMPLE TYPE

FFPE, Peripheral Whole Blood, Bone Marrow Aspirate
RESULTS EXPECTED

2 weeks^*

What is FoundationOne Heme?

FoundationOne Heme is a validated Comprehensive Genomic Profiling^† test for hematologic malignancies, sarcomas, pediatric malignancies, or solid tumours where RNA sequencing is desired. FoundationOne Heme is validated to detect the four main classes of genomic alterations in more than 400 cancer-related genes. In addition to DNA sequencing, FoundationOne Heme employs RNA sequencing across more than 250 genes to capture a broad range of gene fusions, common drivers of hematologic malignancies and sarcomas.

Overview

FoundationOne Heme

>400

genes interrogated
>30

select introns profiled
>250

RNA-sequenced genes

A single test that detects the four main classes of genomic alterations for hematologic cancers and sarcomas
Uses both DNA and RNA sequencing for sensitive detection of translocations and fusions
Reports tumour mutational burden (TMB) and microsatellite instability (MSI), which may inform clinical decision making including clinical trial enrollment

Order FoundationOne Heme

We provide physicians the option to order FoundationOne Heme for patients by fax or phone. Physicians must first complete a test requisition form to start the process and can expect results within 2 weeks from the time a specimen is received at the lab location.

Order Genomic Test with Your Doctor

Patients

FoundationOne Heme is ordered by your healthcare provider. Our patient brochure has all the information you and your doctor need to discuss FoundationOne Heme testing.

Download Patient Brochure

Health Care Practitioners

FoundationOne Heme can be ordered by fax or by phone. Please review and complete the provider resources before ordering.

Provider Resources

Questions? We’re here to help.

* Typical turnaround time from receipt of specimen is two weeks

† Comprehensive Genomic Profiling with FoundationOne Heme involves:

Next generation sequencing of the DNA of 406 cancer-related genes known to be clinically relevant to solid tumours
Uniform coverage across the entire coding sequence of each gene plus select introns from 31 genes frequently rearranged in cancer
Next generation sequencing of the RNA of 265 cancer-related genes known to be clinically relevant to solid tumours
Use of hybrid-capture technology to identify base substitutions, insertions/deletions, copy number alterations and rearrangements